bace in 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3161L	BACE-IN-1 acetate	BACE-IN-1 acetate (350228-37-4，Free base)	BACE
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...		BACE
T62181	BACE-IN-1
	BACE-IN-1 is an imidazo[1,2-a]pyridine derivative that inhibits the β-site amyloid precursor protein cleavage enzyme (BACE) sentence.BACE-IN-1 has the potential to investigate diseases involving BACE, such as Alzheimer's...
T10450	BACE1-IN-1		BACE
	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).		BACE
T61206	AChE/BChE/BACE-1-IN-1
	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 ...
T60691	AChE/BChE/BACE-1-IN-2
	AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 val...
T10451	BACE1-IN-2		BACE
	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).		BACE
T10453	BACE1-IN-5		Beta Amyloid , BACE
	BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...		Beta Amyloid , BACE
T10452	BACE1-IN-4		BACE
	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.		BACE
T39484	BACE1-IN-6	BACE1-IN-6
	BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM.
T3161	β-Secretase inhibitor-STA		Beta-Secretase
	BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor		Beta-Secretase
T2S1181	Aloenin	Aloenin A,Aloearbonaside	Beta-Secretase , AChR
	1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.		Beta-Secretase , AChR
T62995	BACE-1 inhibitor 2
	BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
TN3410	Anatabine		Beta Amyloid , IL Receptor , TNF , NF-κB , BACE , COX , STAT
	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and r...
TN1434	Bavachromene		BACE
	Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.		BACE
T81836	Mca-SEVNLDAEFK(Dnp)-NH2
	Mca-SEVNLDAEFK(Dnp)-NH2 is a fluorogenic substrate featuring a 7-methoxycoumarin moiety whose fluorescence is quenched by the adjacent 2,4-dinitrophenyl group through resonance energy transfer. This compound serves as a ...
T79299	HAChE-IN-3		Monoamine Oxidase
	hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This com...		Monoamine Oxidase
T62180	CB1/2 agonist 2
	CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand with Ki of 3.5 nM and 1.2 nM, respectively. CB1/2 agonist 2 is a full agonist of CB1 and a competitive inverse agonist of CB2. BACE-IN-1 is a com...